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NF2, as well as NF1, is an autosomal dominant disease. In patients NF2 is registered less often, than NF1, in 1 of 50000 newborns. Gene NF2 is located in 22th chromosome (22q12) and codes synthesis of tumoral growth suppressor – merlin protein, or schwannomin which functions as membranous organizer and provides, first of all, construction and functioning of a cellular skeleton. This protein has the greatest importance for proliferation regulation of cells with neuroectodermal origins. If NF2 allelic gene is damaged due to symmetric mutation or loss of heterozygosity in 22nd chromosome, synthesis of normal merlin in a cell stops, dynamic balance of growth regulation is shifted to proliferation, and therefore benign tumoral growth appears. NF2 gene has high penetrance. Practically in all of its carriers the disease develops by 60 years. Developing at NF2 tumors are benign, but more biologically aggressive, than at NF1.
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Bioplasm machine-research of urinary bladder

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Three-dimensional Metatron hunter-graphy was carried with Metatron-4025 (IPP, Russia) system

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Possibilities of non-linear method in diagnostics of adrenals tumors

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