Metatron ipp hunter system
Metatron ipp hunter
system has axial resolution of 30 µm. Application of this device allows to study
epidermis on cellular and sub-cellular levels.
Nowadays objectives and limits of three-dimensional NLS-ultramicroscanning research in dermatology have become very broad.
The following has become real:
– evaluation of treatment efficiency of diseases characterized by skin sclerosis (localized scleroderma, generalized scleroderma), edematous (lipo-dermatosclerosis) and chronic inflammatory (psoriasis) dermatosis;
– measuring skin tumors invasion extent and monitoring after surgical interventions, cryo- and laser therapy at melanotic cancer, basal-like cancer, hemangioma, fibroma, seborrheic keratosis;
– study of local and system medications’ effect to skin (corticosteroids, estradiol).
In accordance with a methodology the metatron ipp hunter-ultramicroscanning diagnostics of skin diseases must be carried out by comparing of affected area with healthy skin at counterlateral homological area.
At NLS-graphy with use of non-linear sensors of 4.9 GHz frequency, normal skin is represented by three layers: epidermis, derma and subcutaneous tissue. Regional and age-related peculiarities of skin thickness are conditioned by derma thickness mainly, which depends in the first place on collagen content in it.
It is considered that at NLS-study with sensor frequency of 1.4 GHz, normal epidermis is visualized poorly, because real thickness of epidermis is 0.02 – 0.5 mm, which is a limit of resolution for system of this class.
Epidermis is a moderately chromogenic structure (2-3 points at Fleindler’s scale), chromogeneity of which depends on thickness and desquamation rate of horny layer.
According to El Gammal S. et al. who used metatron ipp hunter system with non-linear sensor of 4.9 GHz operating frequency, horny and malpighian layers of epidermis may be differentiated.
Super-high-frequency non-linear sensors allow to research more superficial papillary layer and underlying reticular layer of derma, The latter is characterized by more homogeneous structure.
In a healthy skin there are small areas, which are located in derma and correspond to hair follicles, vessels and sebaceous glands. Hypoderm at NLS-grpahy is represented as hypochromogenic and achromogenic layer (1-2 points on Fleindler’s scale), because mainly it consists of relatively homogeneous fat tissue. In this layer more chromogenic strips may be found, which represent connective interseptums.
Analysis of references showed that metatron ipp hunter-research of skin often applied at various oncologic diseases. To study skin tumors both two-dimensional and three-dimensional metatron ipp hunter-graphy may be applied. In majority of cases tumors are represented as areas of increased chromogeneity, more or less separated from derma. It is impossible to define histological character of a tumor on the basis of metatron ipp hunter-graphy only.
For differential diagnostics of such skin tumors as hemangioma or melanoma, modes of ultramicroscanning together with spectral-entropic analysis (SEA) may be successfully applied.
Using metatron ipp hunter-graphy makes
possible to study malignant melanomas. Melanomas at metatron ipp hunter-research
are spindle shaped, quire homogeneous in structure and clearly separated from
surrounding tissues. We noted high precision in evaluation of neoplasms’ size,
which were confirmed by comparison of data acquired with
metatron ipp hunter-study of a tumor before surgical intervention and by
histological tests after operation. According to other data, despite good
visualization of a tumor at metatron ipp hunter-graphic study, the major problem
is to distinguish tumor parenchyma from surrounding inflammatory infiltrate,
because they look like single hyperchromogenic structure. Thus size of some
tumors may be overstated at metatron ipp hunter-study. As studies of Ulrich J.
et al. show, accuracy of tumor size evaluation increases greatly if we exclude
from analysis tumors with extensive inflammatory infiltrate or nevus-associated
melanomas when we apply SEA.
Nowadays objectives and limits of three-dimensional NLS-ultramicroscanning research in dermatology have become very broad.
The following has become real:
– evaluation of treatment efficiency of diseases characterized by skin sclerosis (localized scleroderma, generalized scleroderma), edematous (lipo-dermatosclerosis) and chronic inflammatory (psoriasis) dermatosis;
– measuring skin tumors invasion extent and monitoring after surgical interventions, cryo- and laser therapy at melanotic cancer, basal-like cancer, hemangioma, fibroma, seborrheic keratosis;
– study of local and system medications’ effect to skin (corticosteroids, estradiol).
In accordance with a methodology the metatron ipp hunter-ultramicroscanning diagnostics of skin diseases must be carried out by comparing of affected area with healthy skin at counterlateral homological area.
At NLS-graphy with use of non-linear sensors of 4.9 GHz frequency, normal skin is represented by three layers: epidermis, derma and subcutaneous tissue. Regional and age-related peculiarities of skin thickness are conditioned by derma thickness mainly, which depends in the first place on collagen content in it.
It is considered that at NLS-study with sensor frequency of 1.4 GHz, normal epidermis is visualized poorly, because real thickness of epidermis is 0.02 – 0.5 mm, which is a limit of resolution for system of this class.
Epidermis is a moderately chromogenic structure (2-3 points at Fleindler’s scale), chromogeneity of which depends on thickness and desquamation rate of horny layer.
According to El Gammal S. et al. who used metatron ipp hunter system with non-linear sensor of 4.9 GHz operating frequency, horny and malpighian layers of epidermis may be differentiated.
Super-high-frequency non-linear sensors allow to research more superficial papillary layer and underlying reticular layer of derma, The latter is characterized by more homogeneous structure.
In a healthy skin there are small areas, which are located in derma and correspond to hair follicles, vessels and sebaceous glands. Hypoderm at NLS-grpahy is represented as hypochromogenic and achromogenic layer (1-2 points on Fleindler’s scale), because mainly it consists of relatively homogeneous fat tissue. In this layer more chromogenic strips may be found, which represent connective interseptums.
Analysis of references showed that metatron ipp hunter-research of skin often applied at various oncologic diseases. To study skin tumors both two-dimensional and three-dimensional metatron ipp hunter-graphy may be applied. In majority of cases tumors are represented as areas of increased chromogeneity, more or less separated from derma. It is impossible to define histological character of a tumor on the basis of metatron ipp hunter-graphy only.
For differential diagnostics of such skin tumors as hemangioma or melanoma, modes of ultramicroscanning together with spectral-entropic analysis (SEA) may be successfully applied.
评论
发表评论